I-35 enters Missouri near downtown Kansas City and serves as the west and north legs of the Downtown freeway loop. Along the north edge of the loop, I-35 joins with I-70. Upon leaving the loop, Interstate 29 begins, concurrent with I-35. The two interstates cross the Missouri River together on the Paseo Bridge.
After crossing the river, I-29 and I-35 split. I-35 heads north to Cameron, Missouri, and then continues northward to the Iowa state line.